Bone Tissue Engineering for Dentistry and Orthopaedics

Bone Tissue Engineering for Dentistry and Orthopaedics

Bone has a strong capacity for self-repair; however, conditions such as complex trauma, tumor, infection, and congenital disorders, which can cause large bone defects and resorption, often result in devastating deficits of dental and skeletal tissues. Clinically, this can lead to nonunion of bone and the loss of functional support to surrounding tissues, with the consequence of significant impa...

Aligned and random nanofibrous nanocomposite scaffolds for bone tissue engineering

Aligned and random nanocomposite nanofibrous scaffolds were electrospun from polycaprolactone (PCL), poly (vinyl alcohol) (PVA) and hydroxyapatite nanoparticles (nHA). The morphology and mechanical characteristics of the nanofibers were evaluated using scanning electron microscopy and tensile testing, respectively. Scanning electron microscopy revealed fibers with an average diameter of 123 ± 3...

Poly(lactic acid) (PLA) Nanofibers for Bone Tissue Engineering

Tissue Engineering in Orthopaedics and Musculoskeletal Sciences

Orthopaedic surgery as a speciality lends itself well to tissue engineering. Many musculoskeletal tissues are frequently damaged or lost in injury and disease, and show a limited capacity for repair. Although orthopaedic surgery has been successful in replacing cartilage, the coming years will establish whether a shift from replacement towards regeneration of tissue is feasible. There has been ...

Hydroxyapatite from Fish for Bone Tissue Engineering: A Promising Approach

Natural or synthetic hydroxyapatite (HA) has been frequently used as implant materials for orthopaedic and dental applications, showing excellent bioactivity, adequate mechanical rigidity and structure, osteoconductivity and angiogenic properties, no toxicity, and absence of inflammatory or antigenic reactions. HA can be easily synthesized or extracted from natural sources, such as bovine bone....